A CLOSE-UP VIEW OF A CFTR RELATIVE

The first x-ray crystal structure of an ABC transporter appeared in the September 7th, 2001 issue of Science, and may provide significant insight into the structure and function of CFTR.   In their article, the authors Geoffrey Chang and Christopher Roth are quick to point out, however, that significant differences probably exist between this ABC superfamily member from a bacteria and CFTR as well as some similarities.   More...

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Purified CFTR (on an SDS-PAGE Gel below).    

 

CFTR, a human chloride ion channel,expressed in insect cells. 

 

Ion Channel Glossary